Cont Lens
Anterior Eye. 2010 Apr;33(2):93-9.
Evaluation
of the effects on conjunctival tissues of Optive eyedrops over one month
usage.
Source
OTG Research & Consultancy, London, UK. mguillon@otg.co.uk
Abstract
The
objective was to compare the effect on conjunctival
tissues of the repeated use, over a one-month period, of Optive
compared to Hylocomod eyedrops
by a population of dry eye sufferers. The rationale for the study was that
among dry eye sufferers who attend eye care practices for symptomatic relief, a
large number present with conjunctival anomalies
evidenced by tissue staining and that conjunctival
recovery is essential to their successful long term management. The hypothesis
tested was that the decrease in conjunctival staining
with Optive is at least as good, and possibly
greater, than that with Hylocomod. The cohort
population was made up of 47 subjects (11 male and 26 female) aged 42+/-16
years with at least mild dry eye symptoms and conjunctival
and/or corneal staining. The population included contact lens wearers (n=26)
and non-wearers (n=21). The subjects were randomly allocated to use one of the
two study products; they were instructed to use the products as often as needed
but at least three times a day. Conjunctival staining
was rated on forced choice scales and measured objectively using digital
photographs and image analysis. The findings showed that, whereas the staining
at the start of the investigation was similar (p=0.318-0.664), staining after
one month of use was significantly less with Optive
than Hylocomod (p=0.028-0.002). The results
demonstrated that the regular use of Optive over one
month was significantly superior to Hylocomod in
improving conjunctival status by producing a greater
reduction in the staining of dry eye sufferers.
2010 British Contact Lens Association. Published by
Elsevier Ltd. All rights reserved.
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