Cont Lens
Anterior Eye. 2010 Apr;33(2):76-82. Epub 2009 Dec 6.
Effect of
castor oil emulsion eyedrops on tear film composition
and stability.
Maïssa C, Guillon M, Simmons
P, Vehige J.
Source
OTG Research & Consultancy, London, UK. cmaissa@otg.co.uk
Abstract
PURPOSE:
An
emulsion eyedrop containing castor oil has been shown
to modify the tear film lipid layer and increase tear film stability. The
primary objectives of this investigation were to measure the prevalence of
castor oil in the tear fluid over time and quantify the effects on the lipid
layer. A secondary objective was to quantify the initial effects on ocular
symptomatology.
METHODS:
The
investigation was an open label pilot study on 5 normal and 10 dry eye
subjects. A single eyedrop (Castor oil emulsion,
Allergan) was instilled in each eye; the tear film appearance and composition
were monitored for 4h via in vivo visualisation using the Tearscope
and post in vivo tear samples analysis by HPLC.
RESULTS:
Combined
results for both normal and dry eye subjects showed that castor oil was
detected up to 4h after a single eyedrop instillation
and associated with an increase in the level of tear film lipid. The relative
amount of various lipid families was also changed. An increase in tear lipid
layer thickness was significant up to one hour post-instillation for the
symptomatic sub-population. The changes in tear film characteristics were
associated with significantly lower symptoms up to four hours post-instillation
for the symptomatic sub-population.
CONCLUSION:
This
pilot investigation showed that castor oil eyedrops
achieved a residence time of at least four hours post-instillation, producing a
more stable tear film and an associated significant decrease in ocular symptoms
over the entire follow-up period for the symptomatic subjects.
2009 British Contact Lens Association. Published by
Elsevier Ltd. All rights reserved.
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